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    The Science, Studies and References behind Red Light Therapy And Infrared Light Medicine

    on 

    Red Light Therapy is one of the fastest growing trends in the Wellness Industry

    Below Are Links to Our Favorite Studies Demonstrating The Effects of Red Light and Infrared Therapy - over 100 cases providing depth and understanding as to why Light Medicine is one of the greatest discoveries in natural healing, wellness, and rejuvenation for both the mind and body.

    1. History - Frieman, father of LLLT

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390214/

    2. History, Mechanism, Dose, Mitochondrial, Anti-inflammatory

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/

    3. History, Mechanism, Dose, Mitochondrial, Anti-inflammatory

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/

    4. Visible Light therapy vs. Near Infrared Light therapy

    https://www.mamanatural.com/near-infrared-sauna/

    5. History, Mechanism, Dose, Mitochondrial, Antinflammatory

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/

    Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/

    6. Artificial Light and Cancer - Mal Illumination

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/

    7. Artificial Light and Obesity

    https://www.nature.com/articles/ijo2015255

    https://academic.oup.com/aje/article/180/3/245/2739112

    8. Light at night clock and metabolism

    https://academic.oup.com/edrv/article/35/4/648/2354673

    9. History, Mechanism, Dose, Mitochondrial, Antinflammatory

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/

    10. Diabetic Neuropathy

    https://www.researchgate.net/publication/7272502_Improved_foot_sensitivity_and_pain_reduction_in_patients_with_peripheral_neuropathy_after_treatment_with_monochromatic_infrared_photo_energy_-_MIRE

    Hair Loss

    11. https://www.aad.org/media/stats/conditions/skin-conditions-by-the-numbers

    12. https://www.ncbi.nlm.nih.gov/pubmed/23970445

    Wound Healing, dairy cattle, cat tongue

    13. https://www.ncbi.nlm.nih.gov/pubmed/9068161

    14. https://pdfs.semanticscholar.org/7762/57f1debd12c652310bd11d8d53cfc5052c61.pdf

    15. https://www.researchgate.net/publication/312142584_The_photobiomodulation_effect_of_higher-fluence_808- nm_laser_therapy_with_a_flattop_handpiece_on_the_wound_healing_of_the_earthworm_Dendrobaena_veneta_a_brief_report

     

    16. Wound healing LED shows significant speed of recovery with 633nm.

    https://www.ncbi.nlm.nih.gov/pubmed/16581685

    17. Scarring

    https://www.ncbi.nlm.nih.gov/pubmed/26741110

    18. Dermal Abrasions

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766381/

    Stroke

    19. https://www.ncbi.nlm.nih.gov/pubmed/27345389

    20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538543/

    21. https://www.ncbi.nlm.nih.gov/pubmed/17463313/

    22. https://www.ncbi.nlm.nih.gov/pubmed/17678491/

    Osteoporosis

    23. https://www.ncbi.nlm.nih.gov/pubmed/28846932

    Transcranial effect of LED

    24. https://www.researchgate.net/publication/273781132_Red_and_NIR_light_dosimetry_in_the_human_deep_brain

    Brain Injury 

    25. https://www.researchgate.net/publication/229161498_Transcranial_low_level_laser_light_therapy_for_traumatic_brain_injury

    26. https://www.ncbi.nlm.nih.gov/pubmed/17439348

    27. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397203/

    28. https://www.ncbi.nlm.nih.gov/pubmed/11059663

    Sleep

    29. https://www.ncbi.nlm.nih.gov/pubmed/12811613

    30. https://www.ncbi.nlm.nih.gov/pubmed/12811613

    Testosterone replacement

    31. http://connection.ebscohost.com/c/articles/96971683/effects-low-level-laser-therapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats

    Headache Light therapy modulates serotonin levels and blood flow in women with headache. A preliminary study.

    32. https://www.ncbi.nlm.nih.gov/pubmed/26202374

    Dermal Abrasions

    33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766381/

    Tendonitis

    34. https://www.ncbi.nlm.nih.gov/pubmed/226734405

    Fibromayalgia

    35. https://www.ncbi.nlm.nih.gov/pubmed/24801056

    Effectiveness of low-level laser therapy on pain intensity, pressure pain threshold, and SF-MPQ indexes of women with myofascial pain. :10.11607/ofph.2032. Epub 2018 Apr 25.

    Efficacy of Low-Level Laser Therapy in the Treatment of Temporomandibular Myofascial Pain: A Systematic Review and Meta-Analysis.

    36. https://www.ncbi.nlm.nih.gov/pubmed/29697718

    Acne:

    37. https://www.ncbi.nlm.nih.gov/pubmed/16468292

    38. https://www.ncbi.nlm.nih.gov/pubmed/28232927

    Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris.

    39. https://www.ncbi.nlm.nih.gov/pubmed/22615511

     

    Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease.

    40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/

    Depression Long term study

    41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556873/

     

    Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety:

    42. https://www.ncbi.nlm.nih.gov/pubmed/19995444

     

    Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms.

    43. https://www.ncbi.nlm.nih.gov/pubmed/27267860

     

    Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.

    44. https://www.ncbi.nlm.nih.gov/pubmed/27379735

     

    Dementia 

    Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017;35(8):432-441

    45. https://www.ncbi.nlm.nih.gov/pubmed/28186867 dementia, memory, mood

    General Brain Health & Cognitive Performance. 

    Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans.

    46. https://www.ncbi.nlm.nih.gov/pubmed/23200785

    Shining light on the head: Photobiomodulation for brain disorders

    47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/

    Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation

    48. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568598/

    Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis

    49. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777909/

    Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light

    50. https://www.sciencedirect.com/science/article/pii/S1074742707001153

    Improving executive function using transcranial infrared laser stimulation.

    51. https://www.ncbi.nlm.nih.gov/pubmed/26017772

    52. https://www.ncbi.nlm.nih.gov/pubmed/26535475

    Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise.

    53. https://www.ncbi.nlm.nih.gov/pubmed/27220529

    Neurological and psychological applications of transcranial lasers and LEDs.

    54. https://www.ncbi.nlm.nih.gov/pubmed/23806754

    Alzheimers Disease

    Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease

    55. https://www.researchgate.net/publication/263742704_Low- Level_Laser_Therapy_Ameliorates_Disease_Progression_in_a_Mouse_Model_of_Alzheimer's_Disease 

    Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models.

    56. https://www.ncbi.nlm.nih.gov/pubmed/24387311

    Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease.

    57. https://www.ncbi.nlm.nih.gov/pubmed/23946409

    Bipolar

    Is bipolar disorder an inflammatory condition? The relevance of microglial activation.

    58. https://www.ncbi.nlm.nih.gov/pubmed/23196997

    Arthritis

    mice subjected to acute arthritis condition.

    59. https://www.ncbi.nlm.nih.gov/pubmed/28772237

    Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation.

    60. https://www.ncbi.nlm.nih.gov/pubmed/24028507

    Bell's Palsy -

    61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322014/

    Testosterone

    62. The effects of low level laser therapy (LLLT) on the testis in elevating serum testosterone level in rats http://connection.ebscohost.com/c/articles/96971683/effects-low-level-lasertherapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats

    Aging Skin

    Regulation of Skin Collagen Metabolism In VitroUsing a Pulsed 660 nm LED Light Source: Clinical Correlation with a Single- Blinded Study

    63. https://www.sciencedirect.com/science/article/pii/S0022202X15341749

    Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring

    64. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

    ORAL HEALTH

    Low Level Laser Therapy: A Panacea for oral maladies

    65. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639680/

    NUTS AND BOLTS OF LLLT - Survey of Basically Everything treated by LLLT

    66. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288797/

    MECHANISM OF ACTION OF LLLT - dose, etc. Biphasic Dose Response in Low Level Light

    67. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790317/ 

    The role of nitric oxide in low level light therapy

    68. https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy How Mitochondria absorb visible light

    69. https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy

    REVERSAL OF AGING USING RED LIGHT AND NEAR-INFRARED LIGHT THERAPY

    A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.

    70. https://www.ncbi.nlm.nih.gov/pubmed/24286286

    71. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332991/

    Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheeks Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring.

    72. https://www.ncbi.nlm.nih.gov/pubmed/24049929

    73. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

    ELIMINATION OF FAT

    74. Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review 

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769994/

    “Overweight and obesity.” Centers for Disease Control and Prevention (2007). Available:

    75. https://www.cdc.gov/onsidty/data/ad/ult.html

    Sene-fiorense M, Duarte FO, De aquino junior, et al. The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment. Lasers Sung Med. 2015;47(7):634-42

    76. https://www.ncbi.nlm.nih.gov/pubmed/26220050

    Ger Med Sci. 2006 Jul 11:4; Doc05. Influence of water-filtered infrared-A (wiRA) on reduction of local fat and body weight by physical exercise. Mockel F, Hoffman G, Obermuller R, Drobnik W,Schmitz G.

    77. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703221/

    Mcrae E, Boris J. Independent evaluation of low-level laser therapy 635nm for non-invasive body contouring of the waist, hips and thighs. Lasers Surg Med. 2013;45(1):1-7.

    78. https://www.ncbi.nlm.nih.gov/pubmed/23355338

    79. 635nm - 660nm for Fat Loss

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225499/

    80. Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review 

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769994/

    Health After Cancer

    81. Warburg O. Uber den Stoffweschsel der Hefe. Pp253-254

    82. Bianconi E., Piovesan A, Facchin F, et al. An estimation of the number of cells in the human body. Ann Hun Biol 2013:40(6):463-71

    83. https://www.researchgate.net/publication/306325596_Revised_Estimates_for_the_Number_of_Human_and_Bacteria_Cells_in_the_Body

    84. Li, Y., Park, JS., Deng, JH. Et al. Cytochrome c oxidase subunit IV is useful for assembly and respiratory function of the enzyme complex. J Bioenerg, Biomember (2006)38;283

    85. Brown GC, Borutalite V. Nitric Oxide, cytochrome c, and mitochondria. Biochem Soc. Symp. 1999:66;17-25

    https://www.ncbi.nlm.nih.gov/pubmed/10989653 

    LIGHT MEDICINE AND ANIMALS

    Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase.

    86. https://www.ncbi.nlm.nih.gov/pubmed/21356170

    Inflammation in general:

    Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

    87. https://www.ncbi.nlm.nih.gov/pubmed/28748217 

    Veterinary Medicine and Photobiomodulation

    88. http://veterinarymedicine.dvm360.com/photobiomodulation-facts-and-functions-veterinary-rehab 

    An investigation into the depth of penetration of low level laser therapy through the equine tendon in vivo

    89. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113823/

    EYE HEALTH AND WOUND HEALING

    90. https://www.ncbi.nlm.nih.gov/pubmed/26427443 

    Photobiomodulation for the treatment of retinal diseases: a review

    91. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768515/

    Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age‐related macular degeneration

    92. https://www.ncbi.nlm.nih.gov/pubmed/11845369

    93. https://www.ncbi.nlm.nih.gov/pubmed/16120414

    Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy.

    Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and diabetic rats.

    94. https://www.ncbi.nlm.nih.gov/pubmed/24551842/

    Viral Warts

    95. https://www.researchgate.net/publication/269749233_PULSED_DYE_LASER_TREATMENT_FOR_RECALCITRANT_VIRAL_WARTS_AUTO-SIMULTANEOUS_LASER_TREATMENT

    Plantar Warts

    96. https://www.ncbi.nlm.nih.gov/pubmed/16942430?dopt=Citation

    Herpes

    97. https://www.ncbi.nlm.nih.gov/pubmed/16780494?dopt=Citation

    98. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/

    Dermatitis

    99. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/

    Psoriasis

    100. https://www.researchgate.net/publication/320600622_A_clinical_review_of_phototherapy_for_psoriasis

    Improved Sleep & PTSD

    101. https://www.ncbi.nlm.nih.gov/pubmed/24568233

    Thyroid Tissue Generation

    102. https://www.ncbi.nlm.nih.gov/pubmed/22718472

    103. https://thyroidpharmacist.com/articles/lasers-thyroid-tissue-regeneration/

    104. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534372/

    105. https://www.ncbi.nlm.nih.gov/pubmed/20662037

    Muscle Performance and Recovery Effect of low-level laser therapy on muscle adaptation to knee extensor eccentric training

    106. https://www.researchgate.net/publication/269412590_Effect_of_low-level_laser_therapy_on_muscle_adaptation_to_knee_extensor_eccentric_training

    107. Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light.

    108. Cleber Ferraresi et al. 2012

    https://www.ncbi.nlm.nih.gov/pubmed/23626925

    Does Phototherapy Enhance Skeletal Muscle Contractile Function and Postexercise Recovery? A Systematic Review. Paul A Borsa et al. 2013

    109. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554033/ Verifies the benefit of LLLT in all phases of muscle recovery: 107

    110. https://www.unip.br/presencial/comunicacao/publicacoes/ics/edicoes/2010/03_jul-set/V28_n3_2010_p286-288.pdf

    Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis.

    111. https://www.ncbi.nlm.nih.gov/pubmed/29090398

    Photobiomodulation Therapy Improves Performance and Accelerates Recovery of High-Level Rugby Players in Field Test: A Randomized, Crossover, Double-Blind, Placebo-Controlled Clinical Study. Pinto HD et al. 2016

    112. https://www.ncbi.nlm.nih.gov/pubmed/27050245

    Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation. Ferraresi C et al. 2016

    113. https://www.ncbi.nlm.nih.gov/pubmed/25378263

    Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed- Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. Ferraresi C et al. 2016

    114. https://www.ncbi.nlm.nih.gov/pubmed/27088469

    Diabetic Neuropathy

    115. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639677/

    116. https://www.researchgate.net/publication/7272502_Improved_foot_sensitivity_and_pain_reduction_in_patients_with_peripheral_neuropathy_after_treatment_with_monochromatic_infrared_photo_energy_-

    _MIRE

    Bell's Palsy

    117. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838725/

    118. http://www.litecure.com/wp-content/uploads/2016/09/Laser-Bells-Palsy.pdf

    119. https://www.researchgate.net/publication/271346875_Helium_neon_and_diode_laser_therapy_is_an_effective_adjunctive_therapy_for_facial_paralysis

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